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S2), indicating that inactivation of these genes sensitized tumor cells to T cell–mediated killing. Top genes in this group included known neg-ative immune regulators, including Cd274 [encod-ing PD-L1 (16, 17)], Ptpn2 (18), and Serpinb9 (19) (Fig. 1C and fig. S4B). However, the vast major-ity of identified genes had not been previously